Reproductive toxicology. Trichloroethylene.
نویسندگان
چکیده
These centers are: the Agencourt Bioscience Corporation [2] for the Drosophila ananassae, Drosophila mojavensis, and Drosophila virilis sequence data, the Genome Sequencing Center at the Washington University School of Medicine [3] for the Drosophila yakuba, Drosophila simulans, and Caernorhabditis remanei sequence data, the Human Genome Sequencing Center at the Baylor College of Medicine [4] for the Bos taurus and Rhesus macaque genome sequence, the Broad Institute [5] for the Monodelphis domestica genome sequence, and the Sanger Center [6] for the Danio rerio genome sequence.
منابع مشابه
Role of methanogenic and sulfate-reducing bacteria in the reductive dechlorination of tetrachloroethylene in mixed culture.
Several reports have demonstrated biotransformation of tetrachloroethylene at low concentrations under strict anaerobic conditions by sequential reductive dechlorination (Fathepure and Boyd, 1988a; Freedman and Gosset, 1989). During this biodegradation, trichloroethylene (TCE), 1,1dichloroethylene, vinylidene chloride (DCE), and vinyl chloride (VC) are the intermediate products ; ethene or etha...
متن کاملInhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice.
Trichloroethylene is an organic solvent that is primarily used as a degreasing agent for metals. There is increasing evidence in both humans and animal models that trichloroethylene promotes the development of autoimmunity, but little is known about the mechanisms that mediate the effect of trichloroethylene on the immune system. Metabolic activation of trichloroethylene is considered an obliga...
متن کاملSimulation of the toxicokinetics of trichloroethylene, methylene chloride, styrene and n-hexane by a toxicokinetics/toxicodynamics model using experimental data.
The toxicokinetics/toxicodynamics (TKTD) model simulates the toxicokinetics of a chemical based on physiological data such as blood flow, tissue partition coefficients and metabolism. In this study, Andersen and Clewell's TKTD model was used with seven compartments and ten differential equations for calculating chemical balances in the compartments (Andersen and Clewell 1996, Workshop on physio...
متن کاملEffects of trichloroethylene and perchloroethylene on wild rodents at Edwards Air Force Base, California, USA.
Effects of inhalation of volatilized trichloroethylene (TCE) or perchloroethylene (PCE) were assessed based on the health and population size of wild, burrowing mammals at Edwards Air Force Base (CA, USA). Organic soil-vapor concentrations were measured at three sites with aquifer contamination of TCE or PCE of 5.5 to 77 mg/L and at two uncontaminated reference sites. Population estimates of ka...
متن کاملIn silico toxicology: simulating interaction thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene, and 1,1,1-trichloroethane.
In this study, we integrated our understanding of biochemistry, physiology, and metabolism of three commonly used organic solvents with computer simulation to present a new approach that we call "in silico" toxicology. Thus, we developed an interactive physiologically based pharmacokinetic (PBPK) model to predict the individual kinetics of trichloroethylene (TCE), perchloroethylene (PERC), and ...
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 105 شماره
صفحات -
تاریخ انتشار 1997